MENU CLOSE
About Us

Who We Are

Our Social Responsibility

Events

Exhibitions

Activeties

Members

Hospitals

Individuals

Companies

Member Benefits

 
Bio-medical projectsi

State Key Laboratory of Biotherapy

Cooperation

Achievement Exhibition

Scimea Journals

Signal Transduction and Targeted Therapy

News

News Information

 
Home   >  News
30 Oct 2020
342
Molecular Biomedicine | The bone marrow niche components are adversely affected in sepsis
Scimea

Multiple organ dysfunction is an important cause of death in patients with sepsis. However, few studies have focused on the impact of sepsis on bone marrow (BM), especially on the cell components of BM niche. In this study, Prof. Botao Ning et al provdied a investigation of the dynamic change of BM niche components in sepsis process for the first time.


1604045123(1).jpg


Interactions between organs during sepsis play a pivotal role in sepsis pathogenesis. Notably, BM plays an equally important part in sepsis, which contains hematopoietic progenitor cells and supporting niche cells. Niche components of BM do not participate in hematopoiesis, but support hematopoiesis and maintain niche homeostasis. About sepsis, there has been so far much research focused on the regulation of the BM hematopoiesis by the niche component [8, 9], but few dealt with the changes of endothelial cells (ECs), mesenchymal stem cells (MSCs) and immune cells in BM niche.

 

In this study, researchers performed mouse sepsis models by intraperitoneal injection of LPS and cecal ligation and puncture (CLP). The changes of niche major components in the mouse BM among vascular structures, mesenchymal stem cells and Treg cells were observed and analyzed. The results showed that pathological changes in BM was earlier and more prominent than in other organs, and various cell components of the BM niche changed significantly, of which vascular endothelial cells increased transiently with vascular remodeling and the regulatory T cells decreased over a long period of time (Fig. 1). These results indicated that the components of the BM niche underwent series of adaptive changes in sepsis.


image.png

Fig. 1 Changes of BM niche cell components in CLP model with LPS stimulation

 

 

 

Article Access: https://link.springer.com/article/10.1186/s43556-020-00010-3

 

 

                                                                                                                                        

Website for Molecular Biomedicinehttps://www.springer.com/journal/43556

Looking forward to your contributions


"Earthquake Has No Mercy but People Have Love, A Timely Help Warms the Hearts" - Sichuan International Medical Exchange & Promotion Association Donates Materials to the Hospitals in Yibin Changning Disaster Area
Internal Training | On Professional Behavior
Interview | Lai Xintian: Strengths of New Drug R&D in Sichuan, AI Proven Helpful for Efficiency Improvement
Molecular Biomedicine | Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs
Interview | Koichi Tanaka: Insufficient Donor of Organ Transplantation Worldwide, Not in Favor of Xenotransplantation
Latest Events Journals News Members About Us Home
Contact Us

Address: No. 1103-1105, Building 6, S2, Global Center, High-tech Zone, Chengdu

Email: scimea@163.com 

Tel: (0086-)028-63859818   

Fax: (0086-)028-63859818   

Contact: (0086-)19113901604 (wechat:19113901604)


Follow Us
Copyright © 2009-2019 SCIMEA. All rights reserved 蜀ICP备19011649号-1