MedComm | Is there a maximal effect of tranexamic acid in patients undergoing total knee arthroplasty? A randomized controlled trial

addtime：2020-08-27

Surgical trauma after Total knee arthroplasty (TKA) is always companied by significant hyperfibrinolysis, which can lead to considerable blood loss and rising demand for blood transfusions. Therefore, various methods of blood conservation have been studied, including applying antifibrinolytic drugs such as Tranexamic acid (TXA). But the optimal dosing regimen of TXA has not been determined in TKA. In this research, Prof. Fuxing pei et al suggested an optimal dosing regimen among three presented regimens.

Fig. 1 The perioperative levels of FDP (A), D‐dimer (B), CRP (C), and IL‐6 (D) in patients undergoing TKA.

Article Access: https://onlinelibrary.wiley.com/doi/10.1002/mco2.23

Website for MedComm: https://onlinelibrary.wiley.com/journal/26882663

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