MedComm | Insights on the structure–function relationship of human multidrug resistance protein 7 (MRP7/ABCC10) from molecular dynamics simulations and docking studies

ATP-binding cassette (ABC) transporters superfamily mediates multidrug resistance in cancer by extruding structurally distinct chemotherapeutic agents, causing failure in chemotherapy. Among the 49 AB....



Molecular Biomedicine | Targeting regulatory T cells for immunotherapy in melanoma

Regulatory T cells (Tregs) are essential in the maintenance of immunity, and they are also a key to immune suppressive microenvironment in solid tumors. Many studies have revealed the biology of Tregs....


MedComm | Neoantigen-reactive T cell: An emerging role in adoptive cellular immunotherapy

Adoptive cellular immunotherapy harnessing the intrinsic immune system for precise treatment has exhibited preliminary success against malignant tumors. As one of the emerging roles in adoptive cellul....



Molecular Biomedicine | GMPPB-congenital disorders of glycosylation associate with decreased enzymatic activity of GMPPB

The congenital disorders of glycosylation (CDG) are a family of metabolic diseases in which glycosylation of proteins or lipids is deficient. GDP-mannose pyrophosphorylase B (GMPPB) mutations lead to ....


Mol Biomed

MedComm | Roles of hepatic atypical protein kinase C hyperactivity and hyperinsulinemia in insulin‐resistant forms of obesity and type 2 diabetes mellitus

Diet‐induced obesity, the metabolic syndrome, type 2 diabetes (DIO/MetS/T2DM), and their adverse sequelae have reached pandemic levels. In mice, DIO/MetS/T2DM initiation involves diet‐dependent increa....



Molecular Biomedicine | Interplay between SMAD2 and STAT5A is a critical determinant of IL-17A/IL-17F differential expression

Interleukins (IL)-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-hel....


Mol Biomed

MedComm | Small extracellular vesicles‐based cell‐free strategies for therapy

Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs are an intercellu....



Molecular Biomedicine | Cancer non-stem cells as a potent regulator of tumor microenvironment: a lesson from chronic myeloid leukemia

Pluripotent stem cells in embryo can self-renew and can generate all mature cell types in the body as their potency to self-renew progressively decreases. Adult organs possess populations of tissue-re....


Mol Biomed

MedComm | Autophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling

Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregul....