MedComm | Targeting cancer cachexia: Molecular mechanisms and clinical study

Crosstalk in the metabolism organs of cancer cachexia. Cancer cachexia is a complex systemic catabolism syndrome characterized by muscle wasting. It affects multiple distant organs and their crosstalk....



MedComm | Targeting epigenetic regulators for inflammation: Mechanisms and intervention therapy

Intervention therapy of epigenetic regulators targeting inflammation-related diseasesEmerging evidence indicates that resolution of inflammation is a critical and dynamic endogenous process for host t....



MedComm | Molecular mechanisms and therapeutic target of NETosis in diseases

The roles of process of neutrophil extracellular trap (NET) formation (NETosis) in multiple diseasesEvidence shows that neutrophils can protect the host against pathogens in multiple ways, including t....



MedComm | Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities

Immunomodulatory actions of HSPs in autoimmune diseasesThe heat shock proteins (HSPs) are ubiquitous and conserved protein families in both prokaryotic and eukaryotic organisms, and they maintain cell....



Molecular Biomedicine | Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy

Schematic of the PI3K/AKT/mTOR and Raf/MEK/ERK signaling pathways.The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by mutations and chromosomal translocation in vital targets. The PI3....


Mol Biomed

Molecular Biomedicine | Development of therapeutic antibodies for the treatment of diseases

Primary indications for antibody therapeutics are approved across the globe and in late-stage clinical studies sponsored by commercial firmsSince the first monoclonal antibody drug, muromonab-CD3, was....


Mol Biomed

Molecular Biomedicine | CRISPR/Cas systems usher in a new era of disease treatment and diagnosis

Mechanisms of CRISPR/Cas system, BE and PEThe discovery and development of the CRISPR/Cas system is a milestone in precise medicine. CRISPR/Cas nucleases, base-editing (BE) and prime-editing (PE) are ....


Mol Biomed

Molecular Biomedicine | The role of the gut microbiota in health and cardiovascular diseases

The gut microbiota helps maintaining the balance of the mucosal barrier and immune homeostasisThe gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithe....


Mol Biomed

Molecular Biomedicine | Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy

The coat protein mediated vesicle formationIntracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelle....


Mol Biomed