MedComm | Advances in pathogenesis and precision medicine for nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a squamous carcinoma involving genetic predisposition, infection with Epstein-Barr virus (EBV), and environmental factors, with apparent geographical and racial distr....

2021-02-10

MedComm

 
Molecular Biomedicine | GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Ran (Ras-related nuclear) protein is a member of the Ras superfamily of small GTPases. Like other GTPases, Ran switches between GDP-bound (inactive) and GTP-bound (active) states. Multiple missense mu....

2021-02-07

Mol Biomed

 
MedComm | Lipid metabolism in cancer progression and therapeutic strategies

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signa....

2021-01-31

MedComm

 
Molecular Biomedicine | RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers

IPlatinating agents such as cisplatin and carboplatin are commonly used in the treatment of ovarian cancer. However not all patients respond and the development of intrinsic or acquired resistance to ....

2021-01-28

Mol Biomed

 
MedComm | A cyclic peptide retards the proliferation of DU145 prostate cancer cells in vitro and in vivo through inhibition of FGFR2

As a group of RTKs family, fibroblast growth factor receptors (FGFRs) play critical roles in many key behaviors, including cell proliferation, migration, differentiation, and survival. As their ligand....

2021-01-18

MedComm

 
Molecular Biomedicine | Multimodality molecular imaging of the alveolar-capillary barrier in lung disease using albumin based optical and PET tracers

Inflammatory changes caused by viruses, bacteria, exposure to toxins, commonly used drugs and even surgical intervention have the potential of causing abnormal epithelial permeability, which is manife....

2021-01-14

Mol Biomed

 
MedComm | Visualized analysis of trends and hotspots in global oral microbiome research: A bibliometric study

The oral microbiome contains numerous bacteria, which directly or indirectly participate in various human functions and continuously exchange signals and substances with the human body, significantly ....

2021-01-12

MedComm

 
MedComm | Incidence and risk factors of second primary cancer after the initial primary human papillomavirus related neoplasms

Human papillomavirus (HPV) infection is a common viral infection, with its relatively high prevalence (11% in oral cavity, 26.8% for females in genital organs, 14% for females in anus, 45.2% for males....

2020-12-31

MedComm

 
Molecular Biomedicine | Nose to brain delivery of antiretroviral drugs in the treatment of neuroAIDS

More than 35 years ago, HIV (Human Immunodeficiency Virus) was reported as a unique infection with apparent death. Nowadays, NeuroAIDS (Neuro Acquired Immunodeficiency Syndrome) or HIV (Human Immunode....

2020-12-29

Mol Biomed