Activation of PI3K/AKT pathway is one of the most recurrent resistant mechanisms for BRAF-targeted therapy, and the combination of MAPK and PI3K/AKT inhibitors becomes one of the most promising regime....
2020-11-20
Mol Biomed
Antiapoptotic Bcl-2 family members, including Bcl-xL, are often overexpressed in a variety of cancers through genetic alterations. Bcl-xL is wellknown for its antiapoptotic function, which is critica....
2020-10-29
MedComm
Biological drugs are revolutionising the treatment and management of many serious illnesses including cancer, autoimmune disorders, and rare genetic diseases, with about a third of all new drug approv....
2020-11-10
Mol Biomed
Researchers summerized the role cGAS/STING pathway plays in various pathological and physiological process and emphasized its involvment in some “nontraditional” way.
2020-09-20
Mol Biomed
Ovarian cancer is considered to be the most lethal gynecologic malignancy, and despite the development of conventional therapies and new therapeutic approaches, the patient's survival time remains sho....
2020-10-22
MedComm
Prof. Yongyou Zhang provided a detailed discussion of the development of ChIP-seq & ATAC-seq and their current applications in scientific research.
2020-10-10
Mol Biomed
In this study, Prof. Botao Ning et al provdied a investigation of the dynamic change of BM niche components in sepsis process for the first time.
2020-10-30
Mol Biomed
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including n....
2020-10-07
STTT
Cancer is one of the most common disease worldwide, with complex changes and certain traits which have been described as “The Hallmarks of Cancer.” Despite increasing studies on in-depth investigation....
2020-08-31
Mol Biomed