MedComm Introduction

MedComm is a peer-reviewed, online open access (OA) journal. The journal publishes a wide variety of works that provide novel insights into all aspects of medicine on the basis of novelty, timeliness



Molecular Biomedicine Introduction

Molecular Biomedicine is a peer-reviewed, online open access (OA), multidisciplinary journal that publishes the pioneer works of biomedicine, emphasizing on pathogenic mechanism and innovative


Mol Biomed

Signal Transduction and Targeted Therapy Introduction

Signal Transduction and Targeted Therapy is an open access journal, which aims to accomplish timely publication of the latest discoveries and progress in both basic science and clinical research



MedComm | Combinatorial technology revitalized by DNA-encoding

Combinatorial chemistry invented nearly 40 years ago was welcomed with enthusiasm in the drug research community. The method offered access to a practically unlimited number of new compounds. The new ....



Molecular Biomedicine | Scientific and clinical implications of genetic and cellular heterogeneity in uveal melanoma

The study of cancer dates back as far as centuries B.C. but it was not until the seventeenth century A.D. that research was properly documented and uncontrolled growth of body cells was described. Ove....


Mol Biomed

Molecular Biomedicine | E3 ubiquitin ligases: styles, structures and functions

E3 ubiquitin ligases are a large family of enzymes that join in a three-enzyme ubiquitination cascade together with ubiquitin activating enzyme E1 and ubiquitin conjugating enzyme E2. E3 ubiquitin lig....


Mol Biomed

MedComm | Two novel strategies to overcome the resistance to ALK tyrosine kinase inhibitor drugs: Macrocyclic inhibitors and proteolysis-targeting chimeras

Lung cancer is the most malignant tumor in the worldwide. About 3%-5% non-small cell lung cancer (NSCLC) patients carry anaplastic lymphoma kinase (ALK) gene fusions and receive great benefits from AL....



Molecular Biomedicine | miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα

Tamoxifen resistance (TamR) prevents ER-positive breast cancer patients from benefitting from endocrine therapy, and miR-221 or miR-222 plays vital roles in inducing TamR. In this study, we designed s....


Mol Biomed

MedComm | Molecular mechanisms of chemo- and radiotherapy resistance and the potential implications for cancer treatment

Cancer is a leading cause of death worldwide. Surgery is the primary treatment approach for cancer, but the survival rate is very low due to the rapid progression of the disease and presence of local ....