Molecular Biomedicine | Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy

Activation of PI3K/AKT pathway is one of the most recurrent resistant mechanisms for BRAF-targeted therapy, and the combination of MAPK and PI3K/AKT inhibitors becomes one of the most promising regime....

2020-11-20

Mol Biomed

 
MedComm | Functional impact of cancer patient-associated Bcl-xL mutations

Antiapoptotic Bcl-2 family members, including Bcl-xL, are often overexpressed in a variety of cancers through genetic alterations. Bcl-xL is wellknown for its antiapoptotic function, which is critica....

2020-10-29

MedComm

 
Molecular Biomedicine | Developing inhaled protein therapeutics for lung diseases

Biological drugs are revolutionising the treatment and management of many serious illnesses including cancer, autoimmune disorders, and rare genetic diseases, with about a third of all new drug approv....

2020-11-10

Mol Biomed

 
Molecular Biomedicine | cGAS/STING: novel perspectives of the classic pathway

Researchers summerized the role cGAS/STING pathway plays in various pathological and physiological process and emphasized its involvment in some “nontraditional” way.

2020-09-20

Mol Biomed

 
MedComm | Effective antitumor activity of 5T4‐specific CAR‐T cells against ovarian cancer cells in vitro and xenotransplanted tumors in vivo

Ovarian cancer is considered to be the most lethal gynecologic malignancy, and despite the development of conventional therapies and new therapeutic approaches, the patient's survival time remains sho....

2020-10-22

MedComm

 
Molecular Biomedicine | Profiling chromatin regulatory landscape: insights into the development of ChIP-seq and ATAC-seq

Prof. Yongyou Zhang provided a detailed discussion of the development of ChIP-seq & ATAC-seq and their current applications in scientific research.

2020-10-10

Mol Biomed

 
Molecular Biomedicine | The bone marrow niche components are adversely affected in sepsis

In this study, Prof. Botao Ning et al provdied a investigation of the dynamic change of BM niche components in sepsis process for the first time.

2020-10-30

Mol Biomed

 
STTT | NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators to maintain physiologic processes, enabling the plastic cells to adapt to environmental changes including n....

2020-10-07

STTT

 
Molecular Biomedicine | Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs

Cancer is one of the most common disease worldwide, with complex changes and certain traits which have been described as “The Hallmarks of Cancer.” Despite increasing studies on in-depth investigation....

2020-08-31

Mol Biomed