Molecular Biomedicine | The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding

C11ORF94 is a vertebrate derived transmembrane protein highly expressed in testisSperm-oocyte membrane fusion is necessary for mammalian fertilization. The factors that determine the fusion of sperm w....


Mol Biomed

Molecular Biomedicine | Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Cellular properties of the photosensitizer ICG in vitroPhotodynamic therapy (PDT) has shown impressive therapeutic effects on various types of cancers by reactive oxygen species (ROS) generation and i....


Mol Biomed

Molecular Biomedicine | MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis

Expression of miR-379-5p is decreased in vitro/in vivo/in clinic.Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driv....


Mol Biomed

Molecular Biomedicine | Significant perspectives on various viral infections targeted antiviral drugs and vaccines including COVID-19 pandemicity

Classification of infective human viral diseases and their characteristic sub division and familyA virus enters a living organism and recruits host metabolism to reproduce its own genome and proteins.....


Mol Biomed

Molecular Biomedicine | A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire

Schematic diagram of obtain CDR3 of neutralizing antibodies against SARS-CoV-2Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies,....


Mol Biomed

COVID-19 metabolism: Mechanisms and therapeutic targets

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates antiviral signaling, immune response, and cell metabolism in human body. Viral genome and proteins hijack host metabolic netwo....


MedComm | The molecular pathophysiology of depression and the new therapeutics

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the many hypotheses proposed to understand the molecular pathophysiology of depression, it is still unclear. Curre....



MedComm | The SARS-CoV-2 main protease (Mpro): Structure, function, and emerging therapies for COVID-19

The main proteases (Mpro), also termed 3-chymotrypsin-like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β-coronaviruses. Increasing evidence has demonstrated that 3CLpros....



MedComm | Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor

Opioid abuse and addiction have become a global pandemic, posing tremendous health and social burdens. The rewarding effects and the occurrence of withdrawal symptoms are the two mainstays of opioid a....