Molecular Biomedicine | Development of a novel TLR8 agonist for cancer immunotherapy

Toll-like receptors (TLRs) play a vital role in both innate and adaptive immune responses, which means they are also indispensable in tumorigenesis. Up to now, some TLRs, such as TLR8, TLR4, TLR7 and ....

2020-09-10

Mol Biomed

 
Molecular Biomedicine | Revisiting cancer hallmarks: insights from the interplay between oxidative stress and non-coding RNAs

Cancer is one of the most common disease worldwide, with complex changes and certain traits which have been described as “The Hallmarks of Cancer.” Despite increasing studies on in-depth investigation....

2020-08-31

Mol Biomed

 
MedComm | Is there a maximal effect of tranexamic acid in patients undergoing total knee arthroplasty? A randomized controlled trial

Surgical trauma after Total knee arthroplasty (TKA) is always companied by significant hyperfibrinolysis, which can lead to considerable blood loss and rising demand for blood transfusions. Therefore,....

2020-08-27

MedComm

 
MedComm | Interference of miR‐107 with Atg12 is inhibited by HULC to promote metastasis of hepatocellular carcinoma

Highly upregulated in liver cancer (HULC) was proposed as a diagnosis biomarker in hepatocellular carcinoma (HCC). Both HULC and autophagy are closely correlated with Epithelial-mesenchymal transition....

2020-08-20

MedComm

 
Molecular Biomedicine | Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2

Recently, COVID-19 has raised significant public health concerns globally. However, the some pivotal structure of the causative agent, SARS-CoV-2, is yet not quite clear. In this study, Dan Su et al. ....

2020-08-20

Mol Biomed

 
Molecular Biomedicine - Progress in exosome associated tumor markers and their detection methods

In recent years, the tumor-derived exosome has been perceived as a hot and emerging biomarker for various cancers diagnosis and management in non-invasive manner. However, the problem of exosome isola....

2020-08-14

Mol Biomed

 
MedComm | Radiomics‐based model for accurately distinguishing between severe acute respiratory syndrome associated coronavirus 2 (SARS‐CoV‐2) and influenza A infected pneumonia

The spread of coronavirus disease 2019 (COVID‐19) has become a global pandemic and public health problem. Although unprecedented efforts had been concentrated to identify and isolate individuals with ....

2020-08-13

MedComm

 
MedComm | Regulatory T cells: A potential weapon to combat COVID‐19?

Up to May 27th, there are at least 352 460 patients died from COVID-19, attributed to the widely spread novel coronavirus SARS‐CoV‐2. An effective treatment against COVID-19 is desiderated. Song Guo Z....

2020-08-06

MedComm

 
Breaking News! First Publication of Molecular Biomedicine——Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein

A new member of OA at Springer has recently published its first journal article. Molecular Biomedicine is a peer-reviewed, online open access, multidisciplinary journal that publishes the pioneer work....

2020-08-06

Mol Biomed