MedComm | Heat shock proteins: Biological functions, pathological roles, and therapeutic opportunities

Immunomodulatory actions of HSPs in autoimmune diseasesThe heat shock proteins (HSPs) are ubiquitous and conserved protein families in both prokaryotic and eukaryotic organisms, and they maintain cell....



Molecular Biomedicine | Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy

Schematic of the PI3K/AKT/mTOR and Raf/MEK/ERK signaling pathways.The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by mutations and chromosomal translocation in vital targets. The PI3....


Mol Biomed

Molecular Biomedicine | Development of therapeutic antibodies for the treatment of diseases

Primary indications for antibody therapeutics are approved across the globe and in late-stage clinical studies sponsored by commercial firmsSince the first monoclonal antibody drug, muromonab-CD3, was....


Mol Biomed

Molecular Biomedicine | CRISPR/Cas systems usher in a new era of disease treatment and diagnosis

Mechanisms of CRISPR/Cas system, BE and PEThe discovery and development of the CRISPR/Cas system is a milestone in precise medicine. CRISPR/Cas nucleases, base-editing (BE) and prime-editing (PE) are ....


Mol Biomed

Molecular Biomedicine | The role of the gut microbiota in health and cardiovascular diseases

The gut microbiota helps maintaining the balance of the mucosal barrier and immune homeostasisThe gut microbiota is critical to human health, such as digesting nutrients, forming the intestinal epithe....


Mol Biomed

Molecular Biomedicine | Vesicle trafficking and vesicle fusion: mechanisms, biological functions, and their implications for potential disease therapy

The coat protein mediated vesicle formationIntracellular vesicle trafficking is the fundamental process to maintain the homeostasis of membrane-enclosed organelles in eukaryotic cells. These organelle....


Mol Biomed

Molecular Biomedicine | The vertebrate- and testis- specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding

C11ORF94 is a vertebrate derived transmembrane protein highly expressed in testisSperm-oocyte membrane fusion is necessary for mammalian fertilization. The factors that determine the fusion of sperm w....


Mol Biomed

Molecular Biomedicine | Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment

Cellular properties of the photosensitizer ICG in vitroPhotodynamic therapy (PDT) has shown impressive therapeutic effects on various types of cancers by reactive oxygen species (ROS) generation and i....


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Molecular Biomedicine | MicroRNA-379-5p regulates free cholesterol accumulation and relieves diet induced-liver damage in db/db mice via STAT1/HMGCS1 axis

Expression of miR-379-5p is decreased in vitro/in vivo/in clinic.Lipotoxicity induced by the overload of lipid in the liver, especially excess free cholesterol (FC), has been recognized as one of driv....


Mol Biomed