Molecular Biomedicine | Update on treatment and preventive interventions against COVID-19: an overview of potential pharmacological agents and vaccines

The outbreak of coronavirus disease 2019 (COVID-19) triggered by the new member of the coronaviridae family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created an unprecedented ....

2020-12-18

Mol Biomed

 
MedComm | Development of pathological reconstructed high-resolution images using artificial intelligence based on whole slide image

Pathological analysis is an important approach to diagnose diseases, particularly malignant tumors. The whole slide image (WSI), which meets the desired characteristics of high-definition, high-speed,....

2020-12-17

MedComm

 
Molecular Biomedicine | Low dose of emetine as potential anti-SARS-CoV-2 virus therapy: preclinical in vitro inhibition and in vivo pharmacokinetic evidences

The global pandemic of Coronavirus disease 2019 (COVID-19) has attracted extensive drug searching interets for the new coronavirus SARS-CoV-2. Currently, several clinically used “old” drugs have been ....

2020-12-09

Mol Biomed

 
MedComm | Bone marrow mesenchymal stem cell-conditioned medium facilitates fluid resolution via miR-214-activating epithelial sodium channels

Acute lung injury (ALI) is featured with severe lung edema at the early exudative phase, resulting from the imbalance of alveolar fluid turnover and clearance. Mesenchymal stem cells (MSCs) belong to ....

2020-12-07

MedComm

 
MedComm | The biological role of metabolic reprogramming in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, characterized by early metastasis and resistance to all forms of treatment. The extremely high mortality rate of patients wit....

2020-11-27

MedComm

 
Molecular Biomedicine | Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy

Activation of PI3K/AKT pathway is one of the most recurrent resistant mechanisms for BRAF-targeted therapy, and the combination of MAPK and PI3K/AKT inhibitors becomes one of the most promising regime....

2020-11-20

Mol Biomed

 
MedComm | Functional impact of cancer patient-associated Bcl-xL mutations

Antiapoptotic Bcl-2 family members, including Bcl-xL, are often overexpressed in a variety of cancers through genetic alterations. Bcl-xL is wellknown for its antiapoptotic function, which is critica....

2020-11-13

MedComm

 
Molecular Biomedicine | Developing inhaled protein therapeutics for lung diseases

Biological drugs are revolutionising the treatment and management of many serious illnesses including cancer, autoimmune disorders, and rare genetic diseases, with about a third of all new drug approv....

2020-11-10

Mol Biomed

 
Molecular Biomedicine | The bone marrow niche components are adversely affected in sepsis

In this study, Prof. Botao Ning et al provdied a investigation of the dynamic change of BM niche components in sepsis process for the first time.

2020-10-30

Mol Biomed