MedComm | Autophagic activation of IRF‐1 aggravates hepatic ischemia–reperfusion injury via JNK signaling

Increasing evidence has accrued indicating that autophagy is associated with hepatic ischemia–reperfusion injury (IRI). This report demonstrates that interferon regulatory factor‐1 (IRF‐1) was upregul....

2021-02-11

MedComm

 
MedComm | A potent neutralizing nanobody against SARS-CoV-2 with inhaled delivery potential

The world-wide spread of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is the third major coronavirus outbreak in the past 20 years. SARS-CoV-2 is closely related to SARS-CoV, several SARS-....

2021-03-19

MedComm

 
Molecular Biomedicine| Cancer metabolism and intervention therapy

Metabolic reprogramming with heterogeneity is a hallmark of cancer and is at the basis of malignant behaviors. It supports the proliferation and metastasis of tumor cells according to the low nutritio....

2021-02-27

Mol Biomed

 
MedComm | Construction of a risk map to understand the vulnerability of various types of cancer patients to COVID-19 infection

COVID-19 is leading to a global pandemic and invades human cells via ACE2. So ACE2 is considered to be the receptor in host cells for binding to this novel virus. Therefore, the target cells with the ....

2021-02-22

MedComm

 
MedComm | Advances in pathogenesis and precision medicine for nasopharyngeal carcinoma

Nasopharyngeal carcinoma (NPC) is a squamous carcinoma involving genetic predisposition, infection with Epstein-Barr virus (EBV), and environmental factors, with apparent geographical and racial distr....

2021-02-10

MedComm

 
Molecular Biomedicine | GEF-independent Ran activation shifts a fraction of the protein to the cytoplasm and promotes cell proliferation

Ran (Ras-related nuclear) protein is a member of the Ras superfamily of small GTPases. Like other GTPases, Ran switches between GDP-bound (inactive) and GTP-bound (active) states. Multiple missense mu....

2021-02-07

Mol Biomed

 
MedComm | Lipid metabolism in cancer progression and therapeutic strategies

Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy producers, signa....

2021-01-31

MedComm

 
Molecular Biomedicine | RAD50 deficiency is a predictor of platinum sensitivity in sporadic epithelial ovarian cancers

IPlatinating agents such as cisplatin and carboplatin are commonly used in the treatment of ovarian cancer. However not all patients respond and the development of intrinsic or acquired resistance to ....

2021-01-28

Mol Biomed

 
MedComm | A cyclic peptide retards the proliferation of DU145 prostate cancer cells in vitro and in vivo through inhibition of FGFR2

As a group of RTKs family, fibroblast growth factor receptors (FGFRs) play critical roles in many key behaviors, including cell proliferation, migration, differentiation, and survival. As their ligand....

2021-01-18

MedComm