Molecular Biomedicine | Significant perspectives on various viral infections targeted antiviral drugs and vaccines including COVID-19 pandemicity

Classification of infective human viral diseases and their characteristic sub division and familyA virus enters a living organism and recruits host metabolism to reproduce its own genome and proteins.....

2022-07-15

Mol Biomed

 
Molecular Biomedicine | A new strategy: identification of specific antibodies for neutralizing epitope on SARS-CoV-2 S protein by LC-MS/MS combined with immune repertoire

Schematic diagram of obtain CDR3 of neutralizing antibodies against SARS-CoV-2Although the SARS-CoV-2 vaccine has been widely used worldwide, not all individuals can produce neutralization antibodies,....

2022-07-05

Mol Biomed

 
COVID-19 metabolism: Mechanisms and therapeutic targets

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dysregulates antiviral signaling, immune response, and cell metabolism in human body. Viral genome and proteins hijack host metabolic netwo....

2022-08-09

MedComm | The molecular pathophysiology of depression and the new therapeutics

Major depressive disorder (MDD) is a highly prevalent and disabling disorder. Despite the many hypotheses proposed to understand the molecular pathophysiology of depression, it is still unclear. Curre....

2022-07-21

MedComm

 
MedComm | The SARS-CoV-2 main protease (Mpro): Structure, function, and emerging therapies for COVID-19

The main proteases (Mpro), also termed 3-chymotrypsin-like proteases (3CLpro), are a class of highly conserved cysteine hydrolases in β-coronaviruses. Increasing evidence has demonstrated that 3CLpros....

2022-07-14

MedComm

 
MedComm | Mechanism of opioid addiction and its intervention therapy: Focusing on the reward circuitry and mu-opioid receptor

Opioid abuse and addiction have become a global pandemic, posing tremendous health and social burdens. The rewarding effects and the occurrence of withdrawal symptoms are the two mainstays of opioid a....

2022-06-22

MedComm

 
Molecular Biomedicine | Cleavage of the selective autophagy receptor SQSTM1/p62 by the SARS-CoV-2 main protease NSP5 prevents the autophagic degradation of viral membrane proteins

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the coronavirus disease 2019 (COVID-19) global pandemic. Omicron, a new variant of SARS-CoV-2, has the characteristics of strong....

2022-06-03

Mol Biomed

 
Molecular Biomedicine | Characterization of chronic relapsing antibody mediated arthritis in mice with a mutation in Ncf1 causing reduced oxidative burst

Rheumatoid arthritis (RA) is a chronic autoimmune disorder affecting joints with a hallmark of autoantibody production. Mannan-enhanced collagen type II (COL2) antibody induced arthritis (mCAIA) in ne....

2022-05-12

Mol Biomed

 
Molecular Biomedicine | Human Identical Sequences, hyaluronan, and hymecromone ─ the new mechanism and management of COVID-19

COVID-19 caused by SARS-CoV-2 has created formidable damage to public health and market economy. Currently, SARS-CoV-2 variants has exacerbated the transmission from person-to-person. Even after a gre....

2022-05-20

Mol Biomed